Theresa Rienmüller1, Sara Stoppacher1, Mathias Polz1, Sonja Langthaler1, Daniel Ziesel1, Cristoph Leitner1, Marta Nowakowska2, Susanne Scheruebel3, Muammer Ücal2, Karin Kornmüller3, Rainer Schindl4, Tony Schmidt4, Niroj Shrestha4, Christian Baumgartner1

1Institute of Health Care Engineering with European Testing Center of Medical Devices, Graz University of Technology, Austria; 2Department of Neurosurgery, Medical University of Graz, Graz, 8010 Austria; 3Central European Institute of Technology, Brno University of Technology, Purkyňova 123, 61200 Brno, Czech Republic; 4Gottfried Schatz Research Center – Biophysics, Medical University of Graz, Graz, 8010 Austria

The Institute of Health Care Engineering with European Testing Center of Medical Devices focuses on the development and evaluation of new point-of-care and sensor technologies as well as the analysis, modeling, and simulation of biophysical and biomedical processes. A special emphasis lies on the mathematical description of electrophysiological processes. Models of individual ion channels, for example, allow to investigate bioelectric activity of excitable and non-excitable cells and can be used to predict emergent drug effects. In-silico modeling of whole-cell electrophysiology, in contrast is a well-established tool for the description of the membrane potential in excitable cells only. We here introduce the first approach of an in-silico whole-cell ion current model of the non-excitable cell line A549, a commonly used cancer cell line. The developed electrophysiological models can be further extended to elucidate and explain the interaction of a cell with bioelectric devices, such as external electrodes, or patch-clamp measurements. In cooperation with the Institute for Chemistry and Technology of Materials new materials for biological applications are designed and validated.

Presenting author e-mail address: theresa.rienmueller@tugraz.at