Abstracts

ELECTRICAL STIMULATION METHODS FOR THE PRECLINICAL TREATMENT OF TBI SEQUELAE – AN OVERVIEW

Daniel Ziesel1, Marta Nowakowska2, Karin Kornmueller3, Susanne Scheruebel3, Muammer Üçal2, Christian Baumgartner1, Theresa Rienmüller1

1Institute of Health Care Engineering with European Testing Center of Medical Devices, Graz University of Technology, Austria; 2Department of Neurosurgery, Medical University of Graz, Austria; 3Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Biophysics Division, Medical University of Graz, Austria

Electrical stimulation can be used to treat a variety of neurologic disabilities. Only recently, the focus of research has shifted more towards preclinical studies to investigate the underlying mechanisms of how these stimulation methods affect nervous tissue in greater detail. We will present an overview of some of the most prominent electrical stimulation modalities and highlight some preclinical studies that investigate their underlying mechanisms in the treatment of traumatic brain injury (TBI) sequelae. Investigating the mechanisms inducing neuronal modulation and comparing them between different stimulus delivery modalities could lead to new neurological insights and aid in the discovery of innovative concepts for electrical stimulation. The main objective in the future is to find novel stimulation methods that are less invasive and more precise than current approaches.

Presenting author e-mail address: daniel.ziesel@tugraz.at