Abstracts

LOGOS-TBI: LIGHT-CONTROLLED ORGANIC SEMICONDUCTOR IMPLANTS FOR IMPROVED REGENERATION AFTER TRAUMATIC BRAIN INJURY

Muammer Üçal1, Karin Kornmüller2, Theresa Rienmüller2, Susanne Scherübel-Posch3, Rainer Schindl4, Eric Głowacki3, Vedran Derek5, Silke Patz1, Marta Nowakowska1, Tony Schmidt4, Niroj Shrestha4, Daniel Ziesel2, Sara Stoppacher2, Mathias Polz2, Marie Jakešová3, Ludovico Migliaccio3, Anna-Laurence Schachner-Nedherer4, Robert Reimer4, Aleksandar Opančar5.

1Department of Neurosurgery, Medical University of Graz, Graz, 8010 Austria; 2Institute of Health Care Engineering with European Testing Center of Medical Devices, Graz University of Technology, Austria; 3Central European Institute of Technology, Brno University of Technology, Purkyňova 123, 61200 Brno, Czech Republic; 4Gottfried Schatz Research Center – Biophysics, Medical University of Graz, Graz, 8010 Austria; 5Department of Physics, Faculty of Science, University of Zagreb, Bijenička c. 32, 10000, Zagreb, Croatia

TBI is associated with pathologies at the molecular, physiological and structural level, which dramatically impact neuronal circuitry, communication and synchronization within neuronal networks. The disabilities that succeed a nerve trauma could be partially abated by neuromodulation and physiotherapy, albeit not in all cases. Whilst electrical stimulation methods have been used in numerous studies on that quest, recent research invests enormous effort to not only create devices with ultrathin electrodes but also ways to have them function wireless. Photocapacitive devices bear excellent features combining truly capacitive stimulation and enormous room for versatile designs to create devices with unique properties, harvesting the advantages of optoelectronic stimulation, and offering wireless control. LOGOS-TBI is a voluminous research project that brings neuroscientists, applied physicists, biophysicists, ultrastructural biologists and health care engineers of four institutions from three countries. Scientists of Medical University of Graz and Graz University of Technology (Austria), Central European Institute of Technology (Czech Republic), University of Zagreb (Croatia) are dedicated to achieve regenerative responses in the nervous tissue through photostimulation using novel semiconductor photocapacitors. The project was launched in May 2019 and funded by Austrian Science Fund (FWF) “Zukunftskollegs” Program and is open for more cooperation.

Presenting author e-mail address: muammer.uecal@medunigraz.at